Ambrettolide (CAS 28645-51-4) is a synthetic aroma chemical known for its musky and slightly sweet scent profile, reminiscent of natural ambrette seed oil. It is often used in perfumery to impart a warm, sensual character to fragrances, making it a popular choice in both fine and functional perfumes. Ambrettolide typically functions as a base note, providing depth and longevity to compositions, and is frequently blended with floral, fruity, and woody accords. Its versatility allows it to be used in a variety of fragrance types, from light and airy to rich and opulent. In terms of safety and regulatory considerations, Ambrettolide is subject to IFRA guidelines, which may impose restrictions on its usage levels in certain applications. As with many synthetic aroma chemicals, it is important for formulators to be aware of potential allergenic responses, although Ambrettolide is not commonly listed among the major allergens. Overall, Ambrettolide serves as a valuable ingredient in the perfumer's palette, contributing to the complexity and allure of modern fragrance formulations. — AI-generated summary, 2026-09-02.
A soft, elegant macrocyclic musk with a distinctive floral-sweet character reminiscent of ambrette seed. Warm, slightly waxy and skin-like, with a rounded powdery facet that hovers close to the skin. Excellent fixative that lends a luminous, natural musky glow to compositions.AI · claude-opus-4-7
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Perfume and Flavor Chemicals, page 54.
Colorless, somewhat viscous oil.
Soluble in alcohol and oils.
Rich and extremely tenacious floral-musky, sweet odor.
Fixative, modifier-blender.
Used in flavor compositions, particularly in alcoholic beverages.
Many patented methods are known, few are commercially feasible. From Bromo hexadecenoic acid, or from Dihydroxy palmitic acid, or from Aleuritic acid, or from Juniperic acid, etc.