Intensely fecal and animalic at full strength — a sharp, offensive barnyard/mothball note. On extreme dilution it transforms into a warm, narcotic floral facet reminiscent of jasmine and orange blossom, adding carnal depth and radiance to white florals.AI · claude-opus-4-7
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Perfume and Flavor Chemicals, page 1257.
White crystals, becoming reddish or brownish upon exposure to air and daylight.
Very slightly soluble in water, soluble in alcohol and oils.
Very powerful and diffusive, also extremely tenacious odor, in high concentration repulsively unpleasant, only in very low concentration pleasant, sweet, warm, animal, with a note of overripe fruit.
The taste of Skatole is warm, overripe fruity at concentrations below 0.1 ppm, while it becomes more animal near 1 ppm.
Skatole is used in perfume compositions and in artificial Civet bases. Minute traces of this material may introduce just that natural note of 'overmature flower' or 'forest-floor' or other natural decomposition matter, which can be not only tolerable to a fragrance, but sometimes make it much more attractive.
Minute traces are useful in Grape and Cheese imitation flavor, fruit complexes, Nut flavors, etc., highest in Cheese flavor. Concentrations in the end product vary from 0.01 to 1 ppm.
1) from Propionaldehyde-phenylhydrazone with Zinc chloride. 2) from Indole and Ethyl nitrite plus Sodium ethoxide via beta-iso-Nitrosoindole to Skatole. 3) from Acetyl-meta-toluidine in Diethylamine with Potassium-fertiary-Butoxide at high temperature. 4) an old, abandoned synthesis used Strychnine, treated with Calcium hydroxide. 5) Skatole occurs as a natural breakdown product of Tryptophan. This explains partly the occurrence of Skatole in human faeces.