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Iso-Safrole

PROHIBITION · CAP
CAS
94-59-7
EC
Material type
other
Canonical source
document derived
chemicals · No. 2814

Arctander monograph

Perfume and Flavor Chemicals, page 1241.

tenacity · high
warmsweetfloralanisicspicytenacious
MW
162.19
BP
248°C
MP
7°C
Sp.Gr.
Refractive n
Rotation
Appearance

Colorless oily liquid. Solidifies in the cold.

Solubility

Insoluble in water, poorly soluble in propylene glycol and glycerin, soluble in alcohol and oils.

Odor

Warm and sweet, soft, floral-anisic, mildly spicy and tenacious odor. Sweeter, more floral, more anisic, less woody-spicy than Safrole.

Flavor

Sweet, warm, mostly floral taste in concentrations near 30 ppm. Tends to appear perfumey at higher concentrations.

Uses in perfumery

The title material is very well known by name, but hardly ever used as such in perfumery. It serves as an intermediate in the manufacture of Heliotropine, although certain methods avoid this step altogether.

Uses in flavor

Iso-Safrole is not permitted in flavors in the U.S.A., and also banned from food flavors in most other countries.

Production

Produced from Safrole by treatment with potassium or sodium hydroxide in dry state or alcoholic solution, under pressure or at atmospheric pressure.

Document-derived

IFRA restrictions

Prohibition · natural-source cap
The pure material is prohibited as a fragrance ingredient. Natural extracts containing it are permitted only while the concentration in the finished product stays at or below 0.01%. This cap applies uniformly across all 18 IFRA categories.
On the basis of established maximum concentration levels of this substance in commercially available natural sources (like essential oils, extracts and absolutes), exposure to this substance from the use of these oils and extracts is regarded acceptable as long as the total concentration of Safrole, Isosafrole and Dihydrosafrole in the finished consumer product does not exceed 0.01%.
CategoryKindMax %NotesSource
Category 1Prohibition · cap0.01%See note above
DOC
Category 2Prohibition · cap0.01%See note above
DOC
Category 3Prohibition · cap0.01%See note above
DOC
Category 4Prohibition · cap0.01%See note above
DOC
Category 5AProhibition · cap0.01%See note above
DOC
Category 5BProhibition · cap0.01%See note above
DOC
Category 5CProhibition · cap0.01%See note above
DOC
Category 5DProhibition · cap0.01%See note above
DOC
Category 6Prohibition · cap0.01%See note above
DOC
Category 7AProhibition · cap0.01%See note above
DOC
Category 7BProhibition · cap0.01%See note above
DOC
Category 8Prohibition · cap0.01%See note above
DOC
Category 9Prohibition · cap0.01%See note above
DOC
Category 10AProhibition · cap0.01%See note above
DOC
Category 10BProhibition · cap0.01%See note above
DOC
Category 11AProhibition · cap0.01%See note above
DOC
Category 11BProhibition · cap0.01%See note above
DOC
Category 12Prohibition · cap0.01%See note above
DOC

Compliance-support only. Values resolved from the current IFRA corpus; each row cites the document excerpt it came from. Not a substitute for a qualified safety assessor.

IFRA Annex I

Found naturally in

Natural complex substances (NCSs) in which this material typically occurs.

NCSBotanicalTypical %
Ocatea cymbarum oilOcotea cymbarum Kunth92%
Sassafras bark oilSassafras albidum (Nutt.) Nees92%
Camphor Oil, BrownCinnamomum camphora (L.) J.Presl80%
Mace oilMyristica fragrans Houtt.1.7%
Nutmeg ExtractMyristica fragrans Houtt.1.5%
Cinnamon bark extractCinnamomum zeylanicum Blume0.2%
Litsea cubeba oilLitsea Cubeba(Lour.) Pers.0.05%
Cubeb OilPiper cubeba L. f.0.05%
Ravensara aromatica oilRavansara aromatica Sonn. (v. anisata)0.03%
Identity
Aliases · 36
120-58-194-58-61,2-Methylenedioxy-4-propenylbenzene120-58-11,3-Benzodioxole, 5-(1-propenyl)-1,3-Benzodioxole, 5-(2-propenyl)-1,3-Benzodioxole, 5-propyl-3,4-Methylene dioxyallylbenzene3,4-Methylenedioxypropylbenzene4-Allyl-1,2-methylene dioxybenzene5-Allyl-1,3-benzodioxole5-Prop-1-en-1-yl-1,3-benzodioxole5-Propyl-1,3-benzodioxole94-58-694-59-7Iso-safroleSafrole, Isosafrole and Dihydrosafrole1,2-Methylenedioxy-4-propenylbenzene1,3-Benzodioxole, 5-(1-propenyl)-1,3-Benzodioxole, 5-(2-propenyl)-1,3-Benzodioxole, 5-propyl-1,2-Methylenedioxy-4-propylene benzene120-58-1:3,4-Methylene dioxyallylbenzene3,4-Methylenedioxypropylbenzene3,4-Methylenedioxy propylene benzene4-Propenylcatechol methylene ether4-Propylene-1,2-methylenedioxy benzene4-Allyl-1,2-methylene dioxybenzene5-Allyl-1,3-benzodioxole5-Prop-1-en-1-yl-1,3-benzodioxole5-Propyl-1,3-benzodioxole94-58-6:94-59-7:Iso-safroleSafrol
Compliance note. Restriction data is sourced directly from IFRA publications and preserved with its document excerpt. Perfume Foundry is a compliance-support tool — not a substitute for a qualified safety assessor (CPSR / PIF).